/* Self-hosted fonts (SIL Open Font License), no requests to Google */
@font-face{font-family:"ZCC Archivo";font-style:normal;font-display:swap;font-weight:100 900;font-stretch:62% 125%;src:url(fonts/archivo-latin-standard-normal.woff2) format("woff2");unicode-range:U+0000-00FF,U+0131,U+0152-0153,U+02BB-02BC,U+02C6,U+02DA,U+02DC,U+0304,U+0308,U+0329,U+2000-206F,U+20AC,U+2122,U+2191,U+2193,U+2212,U+2215,U+FEFF,U+FFFD}
@font-face{font-family:"ZCC Archivo";font-style:normal;font-display:swap;font-weight:100 900;font-stretch:62% 125%;src:url(fonts/archivo-latin-ext-standard-normal.woff2) format("woff2");unicode-range:U+0100-02BA,U+02BD-02C5,U+02C7-02CC,U+02CE-02D7,U+02DD-02FF,U+0304,U+0308,U+0329,U+1D00-1DBF,U+1E00-1E9F,U+1EF2-1EFF,U+2020,U+20A0-20AB,U+20AD-20C0,U+2113,U+2C60-2C7F,U+A720-A7FF}
@font-face{font-family:"ZCC Serif";font-style:normal;font-display:swap;font-weight:200 900;src:url(fonts/source-serif-4-latin-wght-normal.woff2) format("woff2");unicode-range:U+0000-00FF,U+0131,U+0152-0153,U+02BB-02BC,U+02C6,U+02DA,U+02DC,U+0304,U+0308,U+0329,U+2000-206F,U+20AC,U+2122,U+2191,U+2193,U+2212,U+2215,U+FEFF,U+FFFD}
@font-face{font-family:"ZCC Serif";font-style:normal;font-display:swap;font-weight:200 900;src:url(fonts/source-serif-4-latin-ext-wght-normal.woff2) format("woff2");unicode-range:U+0100-02BA,U+02BD-02C5,U+02C7-02CC,U+02CE-02D7,U+02DD-02FF,U+0304,U+0308,U+0329,U+1D00-1DBF,U+1E00-1E9F,U+1EF2-1EFF,U+2020,U+20A0-20AB,U+20AD-20C0,U+2113,U+2C60-2C7F,U+A720-A7FF}
@font-face{font-family:"ZCC Plex Mono";font-style:normal;font-display:swap;font-weight:400;src:url(fonts/ibm-plex-mono-latin-400-normal.woff2) format("woff2")}
@font-face{font-family:"ZCC Plex Mono";font-style:normal;font-display:swap;font-weight:500;src:url(fonts/ibm-plex-mono-latin-500-normal.woff2) format("woff2")}
/* Layout: research-group page. Institutional header, mission + Figure 1 schematic, tables, method path, study abstract, periodic table, project register, partners, references. */
:root{
  --bg:#FFFFFF; --paper:#FFFFFF; --hero:#F1F7F0; --hero-line:#DCE9DC; --ink:#0F1B15; --muted:#53635A; --line:#DCE4DF; --grid:#F4F7F5;
  --green:#14682F; --green-2:#23843E; --lime:#9CCB4A; --lime-soft:#EEF6E2; --teal:#1F7A86; --teal-soft:#E3F2F3;
  --macro:#14682F; --micro:#7FB33A; --benef:#1F7A86; --on-dark:#FFFFFF;
  color-scheme:light;
  --sans:"ZCC Archivo","Archivo",ui-sans-serif,system-ui,sans-serif; --serif:"ZCC Serif","Source Serif 4",Georgia,"Times New Roman",serif; --mono:"ZCC Plex Mono","IBM Plex Mono",ui-monospace,Menlo,monospace;
  --ease:cubic-bezier(.23,1,.32,1); --nav:52px;
}
*{box-sizing:border-box}
html{scroll-behavior:smooth}
body{margin:0;background:var(--bg);color:var(--ink);font-family:var(--sans);font-size:16px;line-height:1.6}
h1,h2,h3,p{margin:0}
h1,h2,h3{font-family:var(--serif);font-weight:600;text-wrap:balance;letter-spacing:-.01em}
a{color:var(--green);text-decoration-thickness:1px;text-underline-offset:3px}
:focus-visible{outline:2px solid var(--green);outline-offset:3px;border-radius:2px}
.wrap{max-width:1200px;margin-inline:auto;padding-inline:clamp(16px,4vw,40px)}
.mono{font-family:var(--mono)}
section[id]{scroll-margin-top:calc(var(--nav) + 16px)}

/* institutional header */
.inst{border-bottom:1px solid var(--line);font-size:13px;color:var(--muted)}
.inst .wrap{display:flex;justify-content:space-between;gap:16px;padding-block:8px}
.masthead .wrap{display:flex;align-items:center;gap:16px;padding-block:22px}
.mark{width:44px;height:50px;flex:none;color:var(--green)}
.masthead .t{font-family:var(--serif);font-size:clamp(1.3rem,2.4vw,1.75rem);font-weight:600;line-height:1.15}
.masthead .s{font-size:14px;color:var(--muted);margin-top:2px}
.nav{position:sticky;top:0;z-index:20;background:var(--green);color:var(--on-dark)}
.nav ul{display:flex;gap:2px;margin:0;padding:0;list-style:none;overflow-x:auto;scrollbar-width:none;height:var(--nav);align-items:stretch}
.nav ul::-webkit-scrollbar{display:none}
.nav li{display:flex}
.nav a{display:flex;align-items:center;padding:0 14px;color:var(--on-dark);text-decoration:none;font-size:14.5px;font-weight:500;white-space:nowrap;border-bottom:3px solid transparent}
.nav a:hover{background:color-mix(in srgb,var(--on-dark) 10%,transparent)}
.nav a.on{border-bottom-color:var(--lime)}
.nav li:first-child a{padding-left:0}

/* hero */
.band{position:relative;background:var(--hero);overflow:hidden;isolation:isolate;border-bottom:1px solid var(--hero-line)}
.band .pat{position:absolute;z-index:-1;width:min(620px,64vw);pointer-events:none;opacity:.35;top:-110px;right:-170px}
.hero{display:grid;grid-template-columns:minmax(0,.95fr) minmax(0,1.05fr);gap:clamp(28px,5vw,64px);align-items:center;padding-block:clamp(36px,5vw,64px)}
.crumb{font-size:13px;color:var(--muted)}
.crumb a{color:var(--muted)}
.hero h1{font-size:clamp(2.2rem,4.4vw,3.5rem);line-height:1.08;margin-top:14px}
.hero .lead{font-size:clamp(1.05rem,1.35vw,1.16rem);color:var(--ink);max-width:36rem;margin-top:18px}
.facts{display:grid;grid-template-columns:minmax(0,1fr);margin-top:28px;border-top:1px solid var(--hero-line);max-width:36rem}
.facts div{padding:14px 12px 0 0}
.facts b{display:block;font-family:var(--serif);font-size:1.9rem;font-weight:600;line-height:1;color:var(--green)}
.facts span{font-size:13.5px;color:var(--muted)}
figure{margin:0}
.fig1{background:var(--paper);border:1px solid var(--hero-line);border-radius:6px;padding:clamp(12px,2vw,20px)}
.fig1 svg{display:block;width:100%;height:auto}
figcaption{font-size:13.5px;color:var(--muted);margin-top:12px;line-height:1.5}
figcaption b{color:var(--ink)}

/* sections */
.sec{padding-block:clamp(56px,8vw,96px)}
.sec + .sec{border-top:1px solid var(--line)}
.label{font-family:var(--mono);font-size:12.5px;letter-spacing:.08em;color:var(--green);display:block}
.head{max-width:48rem;margin-bottom:clamp(24px,3.5vw,40px);display:flex;flex-direction:column;gap:10px}
.head h2{font-size:clamp(1.8rem,3.2vw,2.5rem);line-height:1.12}
.head p{color:var(--muted);font-size:1.05rem}

/* academic tables */
.tbl-wrap{overflow-x:auto;border-top:2px solid var(--ink);border-bottom:2px solid var(--ink)}
table{width:100%;border-collapse:collapse;font-size:15px;min-width:720px}
caption{caption-side:bottom;text-align:left;font-size:13.5px;color:var(--muted);padding-top:12px}
caption b{color:var(--ink)}
th,td{text-align:left;vertical-align:top;padding:12px 16px 12px 0;border-bottom:1px solid var(--line)}
thead th{font-family:var(--mono);font-weight:500;font-size:12.5px;letter-spacing:.04em;color:var(--muted);border-bottom:1px solid var(--ink)}
tbody tr:last-child td,tbody tr:last-child th{border-bottom:0}
tbody th{font-family:var(--serif);font-weight:600;font-size:16px;white-space:nowrap}
td.num{font-family:var(--mono);font-variant-numeric:tabular-nums;white-space:nowrap;color:var(--green)}
.tcap{font-size:13.5px;color:var(--muted);margin-top:12px;max-width:60rem}
.tcap b{color:var(--ink)}

/* approach path */
.path{position:relative;display:grid;grid-template-columns:repeat(5,minmax(0,1fr));gap:16px}
.path::before{content:"";position:absolute;left:22px;width:calc(80% + 12.8px);top:21px;height:2px;background:var(--line)}
.path .prog{position:absolute;left:22px;top:21px;height:2px;width:calc(80% + 12.8px);background:var(--green);transform-origin:left center;transform:scaleX(var(--p,0));transition:transform 1.6s var(--ease)}
.stage{position:relative;display:flex;flex-direction:column;gap:8px}
.dot{width:44px;height:44px;border-radius:50%;background:var(--paper);border:2px solid var(--line);display:grid;place-items:center;font-family:var(--mono);font-size:13px;color:var(--muted);transition:border-color .4s ease,background-color .4s ease,color .4s ease;position:relative;z-index:1}
.stage.on .dot{border-color:var(--green);background:var(--green);color:var(--on-dark)}
.stage h3{font-size:1.12rem;margin-top:6px}
.stage p{font-size:14.5px;color:var(--muted)}

/* methods: full-bleed video band */
.labx{position:relative;overflow:hidden;isolation:isolate;background:#06141E;color:#E8F1F4;min-height:min(820px,100vh);display:flex;align-items:center;border-top:0!important}
.labx + .sec{border-top:0}
.labx-vid{position:absolute;inset:0;width:100%;height:100%;object-fit:cover;z-index:-2;transform:scale(1.08);transition:transform 12s linear}
.labx.live .labx-vid{transform:scale(1)}
.labx-shade{position:absolute;inset:0;z-index:-1;background:linear-gradient(90deg,rgba(6,20,30,.82) 0%,rgba(6,20,30,.25) 38%,rgba(6,20,30,.35) 56%,rgba(6,20,30,.9) 100%),linear-gradient(0deg,rgba(6,20,30,.7),transparent 30%)}
.labx-in{position:relative;width:100%;display:grid;grid-template-columns:minmax(0,1fr) minmax(0,440px);gap:clamp(24px,6vw,96px);align-items:center}
.labx .label{color:#9CCB4A}
.labx-head{max-width:26rem;display:flex;flex-direction:column;gap:12px;align-self:start}
.labx-head h2{font-size:clamp(1.9rem,3.4vw,2.7rem);line-height:1.1;color:#FFFFFF}
.labx-head p{color:rgba(232,241,244,.78);font-size:1.04rem}
.labx-cap{font-size:13px!important;margin-top:auto;padding-top:10px;border-top:1px solid rgba(232,241,244,.2)}
.labx-cap b{color:#FFFFFF}
.methods{list-style:none;margin:0;padding:8px 24px;display:flex;flex-direction:column;background:rgba(6,20,30,.55);backdrop-filter:blur(14px) saturate(1.2);-webkit-backdrop-filter:blur(14px) saturate(1.2);border:1px solid rgba(156,203,74,.28);border-radius:6px}
.methods li{display:grid;grid-template-columns:34px minmax(0,1fr);gap:2px 12px;padding:16px 0;border-bottom:1px solid rgba(232,241,244,.14);font-size:14.5px}
.methods li:last-child{border-bottom:0}
.methods .n{grid-row:span 2;font-family:var(--mono);font-size:12px;color:#9CCB4A;padding-top:3px}
.methods b{font-family:var(--serif);font-weight:600;font-size:17px;color:#FFFFFF}
.methods li > span:last-child{color:rgba(232,241,244,.75)}


/* Figure 3: protein-protein interaction */
.ppi-grid{display:grid;grid-template-columns:minmax(0,1.35fr) minmax(0,.65fr);gap:clamp(24px,4vw,56px);align-items:start}
.ppi-stage{position:relative;aspect-ratio:4/3;border:1px solid var(--line);border-radius:6px;overflow:hidden;background:radial-gradient(120% 90% at 50% 40%,#FFFFFF 0%,#F2F7F3 70%,#E9F1EB 100%);touch-action:pan-y;cursor:grab}
.ppi-stage.dragging{cursor:grabbing}
.ppi-stage canvas{position:absolute;inset:0;width:100%;height:100%;display:block}
.pl{position:absolute;left:0;top:0;pointer-events:none;font-family:var(--mono);font-size:12px;line-height:1.2;white-space:nowrap;padding:4px 8px;border-radius:3px;background:rgba(255,255,255,.88);border:1px solid var(--line);color:var(--ink);opacity:0;transition:opacity .4s ease}
.ppi-stage.ready .pl{opacity:1}
.pl.sod{border-color:#2E9E4E;color:#14682F}.pl.ccs,.pl.d1{border-color:#1F7A86;color:#155E67}.pl.d3{border-color:#9CCB4A;color:#3F6A12}.pl.metal{border-color:#C4742F;color:#8A4A15}
.ppi-hint{position:absolute;left:12px;bottom:10px;font-size:12px;color:var(--muted);pointer-events:none}
.ppi-side h3{font-size:1.3rem;line-height:1.25}
.ppi-steps{list-style:none;margin:16px 0 0;padding:0;border-top:2px solid var(--ink)}
.ppi-steps li{display:grid;grid-template-columns:28px minmax(0,1fr);gap:12px;padding:13px 0;border-bottom:1px solid var(--line);font-size:15px}
.ppi-steps li span{font-family:var(--mono);font-size:12px;color:var(--green);padding-top:3px}
.ppi-key{display:flex;flex-wrap:wrap;gap:8px 16px;margin-top:16px;font-size:13px;color:var(--muted)}
.ppi-key span{display:inline-flex;align-items:center;gap:7px}
.ppi-key i{width:12px;height:12px;border-radius:2px;background:var(--c)}
.ppi-key i.r{border-radius:50%}

/* study abstract */
.study{display:grid;grid-template-columns:minmax(0,.9fr) minmax(0,1.1fr);gap:clamp(24px,4vw,56px);align-items:start}
.study h3{font-size:clamp(1.35rem,2.3vw,1.7rem);line-height:1.2}
.study .meta{font-size:13.5px;color:var(--muted);margin-top:10px}
.abs{margin-top:20px;display:flex;flex-direction:column;gap:12px;font-size:15.5px}
.abs b{font-family:var(--mono);font-weight:500;font-size:12.5px;letter-spacing:.06em;color:var(--green);margin-right:6px}
.study table{min-width:0;font-size:14.5px}

/* periodic table */
.ni-note{display:grid;grid-template-columns:auto minmax(0,1fr);gap:20px;align-items:center;margin-bottom:28px;padding:18px 20px;background:var(--grid);border-left:3px solid var(--green)}
.word{display:flex;gap:6px}
.tile{position:relative;width:46px;height:52px;border-radius:4px;border:1px dashed var(--line);background:var(--paper);display:grid;place-items:center}
.tile b{font-family:var(--sans);font-weight:700;font-size:1.4rem;color:color-mix(in srgb,var(--ink) 70%,transparent)}
.tile.real{border:0;background:var(--green)}
.tile.real b{color:var(--on-dark)}
.tile.real .z,.tile.real .m{position:absolute;font-family:var(--mono);font-size:8px;color:var(--on-dark)}
.tile.real .z{top:2px;left:4px}.tile.real .m{bottom:2px;left:0;right:0;text-align:center}
.ni-note p{font-size:15px}
.pt-wrap{display:grid;grid-template-columns:minmax(0,1fr) 290px;gap:24px;align-items:start}
.pt-scroll{overflow-x:auto;padding-bottom:6px}
.pt{display:grid;grid-template-columns:repeat(18,minmax(36px,1fr));gap:4px;min-width:700px}
.el{aspect-ratio:1/1.1;border-radius:3px;border:1px solid var(--line);background:var(--paper);display:flex;flex-direction:column;justify-content:center;align-items:center;font:inherit;color:color-mix(in srgb,var(--ink) 35%,transparent);padding:2px;position:relative}
.el i{position:absolute;top:2px;left:4px;font-style:normal;font-family:var(--mono);font-size:9px}
.el b{font-size:15px;font-weight:650}
button.el{cursor:pointer;color:var(--on-dark);border:0;transition:transform .18s var(--ease),box-shadow .2s ease}
button.el:hover,button.el[aria-pressed="true"]{transform:translateY(-2px) scale(1.05);box-shadow:0 8px 18px -10px var(--c);z-index:2}
button.el[aria-pressed="true"]{outline:2px solid var(--ink);outline-offset:2px}
.el.macro{background:var(--macro);--c:var(--macro)}
.el.micro{background:var(--micro);--c:var(--micro);color:#0E1A08}
.el.benef{background:var(--benef);--c:var(--benef)}
.pt-key{display:flex;flex-wrap:wrap;gap:16px;margin-top:14px;font-size:13.5px;color:var(--muted)}
.pt-key span{display:inline-flex;align-items:center;gap:8px}
.pt-key i{width:12px;height:12px;border-radius:2px;background:var(--c)}
.card-el{position:sticky;top:calc(var(--nav) + 20px);border:1px solid var(--line);border-top:2px solid var(--ink);background:var(--paper);padding:20px;display:flex;flex-direction:column;gap:12px}
.big{width:96px;aspect-ratio:1/1.1;border-radius:4px;background:var(--c);color:var(--on-dark);position:relative;display:flex;flex-direction:column;justify-content:center;align-items:center}
.big.micro{color:#0E1A08}
.big i{position:absolute;top:6px;left:8px;font-style:normal;font-family:var(--mono);font-size:11px}
.big b{font-size:2.3rem;font-weight:760;line-height:1}
.big small{position:absolute;bottom:6px;font-family:var(--mono);font-size:11px}
.card-el h3{font-size:1.35rem}
.card-el .cat{font-family:var(--mono);font-size:12.5px;color:var(--muted)}
.card-el p{font-size:15px}

/* project register */
.reg{border-top:2px solid var(--ink)}
.proj{display:grid;grid-template-columns:240px minmax(0,1fr);gap:clamp(20px,4vw,48px);padding-block:26px;border-bottom:1px solid var(--line)}
.proj dl{margin:0;display:grid;gap:8px;font-size:13.5px}
.proj dt{font-family:var(--mono);font-size:11.5px;letter-spacing:.06em;color:var(--muted)}
.proj dd{margin:0 0 4px;color:var(--ink)}
.status{display:inline-flex;align-items:center;gap:6px}
.status::before{content:"";width:8px;height:8px;border-radius:50%;background:var(--green)}
.status.plan::before{background:var(--paper);border:1.5px solid var(--green)}
.proj h3{font-size:clamp(1.3rem,2.2vw,1.6rem);line-height:1.2}
.proj h3 small{display:block;font-family:var(--sans);font-size:15px;font-weight:500;color:var(--muted);letter-spacing:0;margin-top:4px}
.proj p{margin-top:12px;font-size:15.5px;max-width:46rem}
.kw{margin-top:12px;font-size:13.5px;color:var(--muted)}
.kw b{font-family:var(--mono);font-weight:500;font-size:11.5px;letter-spacing:.06em;margin-right:6px}

/* partners */
.partners{display:grid;grid-template-columns:repeat(3,minmax(0,1fr));gap:16px}
.pcard{border:1px solid var(--line);border-top:2px solid var(--ink);padding:20px;display:flex;flex-direction:column;gap:6px}
.pcard h3{font-size:1.12rem;line-height:1.25}
.pcard span{font-size:14px;color:var(--muted)}
.pcard .stars{width:44px;height:44px;margin-bottom:4px}
.pcard.eu{background:var(--teal-soft);border-top-color:var(--teal)}

/* contact */
.contact{display:grid;grid-template-columns:minmax(0,1.2fr) minmax(0,.8fr);gap:clamp(24px,4vw,56px)}
.contact p{font-size:1.05rem;max-width:40rem}
.contact p + p{margin-top:12px}
address{font-style:normal;font-size:15px;line-height:1.7;border-left:3px solid var(--green);padding-left:18px}
address b{font-family:var(--serif);font-size:17px;font-weight:600}

/* references */
.refs ol{margin:0;padding-left:22px;display:grid;gap:10px;font-size:14px;color:var(--ink);max-width:64rem}
.refs li::marker{font-family:var(--mono);color:var(--muted)}
.refs li:target{background:var(--lime-soft)}
.cite{font-size:.72em;line-height:0;margin-left:1px}
.cite a{text-decoration:none;font-family:var(--mono)}
.cite a:hover{text-decoration:underline}

footer{border-top:1px solid var(--line);padding-block:24px;font-size:13px;color:var(--muted)}
footer .wrap{display:flex;justify-content:space-between;flex-wrap:wrap;gap:12px}

.rv{opacity:1}
.rv-wait{opacity:0;transform:translateY(14px)}
.rv-go{opacity:1;transform:none;transition:opacity .8s var(--ease),transform .8s var(--ease)}

@media (max-width:960px){
  .hero,.pt-wrap,.lab,.study,.contact{grid-template-columns:minmax(0,1fr)}
  .card-el{position:static}
  .path{grid-template-columns:minmax(0,1fr);gap:0}
  .path::before{left:21px;top:22px;bottom:22px;width:2px;height:auto}
  .path .prog{left:21px;top:22px;width:2px;height:calc(100% - 44px);transform-origin:center top;transform:scaleY(var(--p,0))}
  .stage{display:grid;grid-template-columns:44px minmax(0,1fr);gap:2px 16px;padding-bottom:20px}
  .stage .dot{grid-row:span 3}
  .stage h3{margin-top:8px}
  .ppi-grid{grid-template-columns:minmax(0,1fr)}
  .pl{font-size:10.5px;padding:3px 6px}
  .proj{grid-template-columns:minmax(0,1fr);gap:14px}
  .proj dl{grid-template-columns:repeat(2,minmax(0,1fr))}
  .partners{grid-template-columns:minmax(0,1fr)}
  .labx{display:block;min-height:0;padding-top:0}
  .labx-vid{position:relative;inset:auto;height:auto;aspect-ratio:16/9;transform:none!important;z-index:0;display:block}
  .labx-shade{background:linear-gradient(180deg,transparent 0,transparent 32vw,#06141E 56.25vw)}
  .labx-in{grid-template-columns:minmax(0,1fr);margin-top:-48px;z-index:1}
}
@media (max-width:520px){
  .inst .wrap span:last-child{display:none}
  .ni-note{grid-template-columns:minmax(0,1fr)}
  .facts b{font-size:1.5rem}
}
@media (prefers-reduced-motion: reduce){ html{scroll-behavior:auto} *{transition:none!important} .rv-wait{opacity:1;transform:none} }

/* WordPress admin bar offset */
.admin-bar .nav{top:32px}
@media (max-width:782px){.admin-bar .nav{top:46px}}
@media (max-width:600px){.admin-bar .nav{top:0}}
img{max-width:100%}